BNT162b2 mRNA COVID-19 vaccine three-dose safety and risk of COVID-19 in patients with myasthenia gravis during the alpha, delta, and omicron wavesArticle Published on 2022-12-012022-11-16 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 변종, [키워드] Administered Affect Alpha BNT162b2 mRNA BNT162b2 mRNA vaccine contribute COVID-19 COVID-19 mortality COVID-19 vaccine develop disease General population Mild morbidity and mortality Myasthenia myasthenia gravis outcome Patient patients raise reduced risk Respiratory failure risk risk of COVID-19 Safety SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 severe disease significantly higher vaccination Vaccine vaccine dose vaccine. [DOI] 10.1007/s00415-022-11303-8 PMC 바로가기
Predict, prevent and manage moral injuries in Canadian frontline healthcare workers and leaders facing the COVID-19 pandemic: Protocol of a mixed methods studyResearch article Published on 2022-12-012022-10-05 Journal: SSM - Mental Health [Category] 바이오마커, [키워드] addition adjusted analysis Biomarker Biomarkers blood sample build collected condition contribute COVID-19 COVID-19 crisis COVID-19 pandemic develop disease emotional event expand frontline healthcare worker generate group Health healthcare healthcare worker Healthcare workers identify Inflammation Injury knowledge mental health Moral Moral injuries observé occur Occurrence participant predict predictor Prevent protocol psychosocial stressor Psychosocial stressors at work Quantitative Quantitative data questionnaire recommendation reduce Research risk Risk factors severity Stress Stressor [DOI] 10.1016/j.ssmmh.2022.100124 [Article Type] Research article
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineageArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] approach Cell culture circulating comparable contribute COVID-19 determine experimental animal models fitness. G496S genetics monoclonal antibodies omicron Omicron BA.1 Omicron BA.2 pathogenicity phenotype predominant receptor-binding motif Replication SARS-CoV-2 SARS-CoV-2 variant sensitivity spike mutation therapeutic trajectory [DOI] 10.1080/22221751.2022.2111977 PMC 바로가기
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection3회분의 BNT162b2 백신 또는 BA.1 감염에 의한 Omicron 하위 계통 및 Deltacron SARS-CoV-2 중화Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] Antibody neutralization BNT162b2 BNT162b2 vaccine contribute convalescent sera dose evade geometric mean geometric mean titre geometric mean titres GMT GMTs highest Identifier immune immune evasion individual infected individual infected individuals Infection Mutation neutralization neutralization activity neutralized of BNT162b2 omicron post-dose SARS-CoV-2 SARS-CoV-2 spike sera titre Trial registration unique USA-WA1/2020 vaccinated individual Vaccine variant variants variants. [DOI] 10.1080/22221751.2022.2099305 PMC 바로가기 [Article Type] Article
Art-science multidisciplinary collaborations to address the scientific challenges posed by COVID-19Article Published on 2022-12-012022-11-15 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Algorithm approach art-based method Asymptomatic individuals Contagion contribute coronavirus COVID COVID-19 COVID-19 pandemic develop Diagnosis Effect experimental design host immunity Human immunology incidence increase Interaction Interpretation Mixed-methods Modification Molecular biology multidisciplinary. nutritional intervention pandemic Pandemics Perspective promote Protean art Protective protective mechanism reduce Research response to vaccination risk SARS-CoV-2 variant SARS-CoV-2 virus Surveillance translate transmission of SARS-CoV-2 Vaccine vector virus virus transmission zoonotic disease [DOI] 10.1080/07853890.2022.2123557 PMC 바로가기
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2Article Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry [DOI] 10.1080/22221751.2022.2117098 PMC 바로가기
Impact of the COVID-19 pandemic on return and risk transmission between oil and precious metals: Evidence from DCC-GARCH modelResearch article Published on 2022-12-012022-10-05 Journal: Resources Policy [Category] 진단, [키워드] addition changed condition contribute correlation COVID-19 pandemic DCC-GARCH debates empirical finding Evidence Impact Oil pandemic positive Precious metals risk seeking The COVID-19 Transmission turn weakened [DOI] 10.1016/j.resourpol.2022.102939 [Article Type] Research article
Clinical course of novel COVID-19 infection in pregnant womenObservational Study Published on 2022-12-012022-10-05 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] alanine aminotransferase analyzed Anemia Anosmia antimicrobial APGAR score Asymptomatic C-reactive protein carbapenem change clinical Clinical course clinical symptom contribute coronavirus cough Course COVID-19 COVID-19 infection CPAP therapy creatinine CRP decrease demographic disease drug Elimination epidemiological erythrocyte excluded form Immunity increase in Infection interferon Laboratory lactate dehydrogenase LDH leukopenia low molecular weight lymphocyte manifestation maternal and perinatal outcomes. mechanical ventilation Mild moderate morbidity Neonatal Neonatal COVID-19 Neonate no evidence of occurred outcome outcomes Oxygenation PCR polymerase chain predictor Pregnancy pregnant women preterm delivery prospective observational study recommendations reported required SARS-CoV-2 Severe case severe COVID-19 Spontaneous Transmission virus women [DOI] 10.1080/14767058.2020.1850683 PMC 바로가기 [Article Type] Observational Study